GNE-900 is a an ATP-competitive, selective, and orally active ChK1 inhibitor with IC50s of 0.0011, 1.5 µM for ChKl, ChK2, respectively. GNE-900 abrogates the G2-M checkpoint, enhances DNA damage, and induces Apoptosis. Gemcitabine (HY-17026) and GNE-900 administration shows anti-tumor activity[1].
Molecular Weight:
367.45
Purity:
98.58
CAS Number:
[1200126-26-6]
Formula:
C23H21N5
Target:
Apoptosis,Checkpoint Kinase (Chk)
Application Notes:
MCE Product type: Reference compound
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