Multitarget AD inhibitor-2 (Compound VN-19) is a multitargeting inhibitor acetylcholinesterase (AChE, IC50=0.14 µM), butyrylcholinesterase (BChE, IC50=11.6 µM), monoamine oxidase B (MAO B, IC50=0.45 µM). Multitarget AD inhibitor-2 inhibits self-induced aggregation of amyloid beta protein Abeta1-42 (inhibition rate is 47.3% at 20 µM), and downregulates the level of ROS in SH-SY5Y (80 inhibition rate at 25 µM). Multitarget AD inhibitor-2 ameliorates the cognitive decline in Scopolamine (HY-N0296)-induced Alzheimers Disease zebrafish models[1].
Molecular Weight:
365.42
Formula:
C22H23NO4
Target:
Cholinesterase (ChE),Monoamine Oxidase
Application Notes:
Reference compound
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