PolQi1 is a selective inhibitor targeting the Poltheta domain of DNA polymerase. PolQi1 inhibits the Poltheta-mediated microhomology end joining (TMEJ/alt-EJ) pathway, reducing insertion/deletion (Indels) and imprecise editing events during DNA repair. PolQi1 can enhance the efficiency and accuracy of homology-directed repair (HDR) or Prime editing, and reduce off-target effects, and in combination with DNA-PK inhibitor AZD-7648 (HY-111783), exert efficient genome editing capabilities with dual pathway regulation. PolQi1 can be mainly used in gene editing research (such as CRISPR-Cas9 or Prime editing system optimization) to improve the precision editing efficiency of difficult-to-edit cells (such as primary hepatocytes and mouse embryos)[1][2][3].
Molecular Weight:
448.77
Purity:
98.42
CAS Number:
[2607139-80-8]
Formula:
C18H14ClF5N4O2
Target:
DNA/RNA Synthesis
Application Notes:
Reference compound
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