hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC50 of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC50 of 0.95-2.81 µM. hDHODH-IN-15 induces ferroptosis in HCT-116, and exhibits antitumor efficacy[1].
Molecular Weight:
338.36
Formula:
C19H18N2O4
Target:
Dihydroorotate Dehydrogenase,Ferroptosis
Application Notes:
MCE Product type: Reference compound1
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