M4 mAChR Modulator-1 (compound 23i) is a M4 mAChR positive allosteric modulator (PAM). M4 mAChR Modulator-1 exhibits significantly greater cooperativity with ACh in beta-arrestin recruitment over G protein activation. M4 mAChR Modulator-1 displays weak PAM effect in G protein-mediated responses, but strong PAM effect in beta-arrestin recruitment[1].
Molecular Weight:
373.45
Formula:
C22H23N5O
Target:
mAChR
Application Notes:
MCE Product type: Reference compound
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