sEH-degrader-1 (Compound 8) serves as an inhibitor for sEH, with IC50 values of 3.8 nM and 210 nM against hsEH and msEH respectively. sEH-degrader-1 can effectively degrade sEH in mouse liver and brown adipose tissue (Red: UC-1728 (HY-114266), black: linker (HY-W248248), Blue: Thalidomide-5-piperazine (HY-W834174))[1].
Molecular Weight:
1015.13
Formula:
C53H65F3N8O9
Target:
Epoxide Hydrolase,PROTACs
Application Notes:
MCE Product type: Reference compound
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