VEGFR-2-IN-51 (compound 19) is an orally active dual-target inhibitor of VEGFR-2 (IC50=15.33 µM) and tubulin (IC50=0.76 µM) with anti-tumor activity. VEGFR-2-IN-51 induces tumor cell apoptosis by reducing mitochondrial membrane potential and increasing reactive oxygen species (ROS) levels. VEGFR-2-IN-51 exerts anti-angiogenic effects by blocking the VEGFR-2/PI3K/AKT signaling pathway. In addition, VEGFR-2-IN-51 has significant anti-proliferative activity against the gastric cancer cell line MGC-803 (IC50=0.005 µM)[1].
Molecular Weight:
466.51
Formula:
C24H22N2O6S
Target:
Apoptosis,Microtubule/Tubulin,Reactive Oxygen Species (ROS),VEGFR
Application Notes:
MCE Product type: Reference compound
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