PBA-AMF can be activated by H2O2 to release Amonafide (AMF) (HY-10982). PBA-AMF selectively inhibited the proliferation of breast cancer cells, while sparing non-cancerous cells. PBA-AMF inhibits tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBA-AMF can be used for research of tumors and other diseases associated with increased H2O2 levels[1].
Molecular Weight:
461.27
Formula:
C24H24BN3O6
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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