TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values of 0.51, 0.46, and 0.48 µM, respectively[1].
Molecular Weight:
441.62
Purity:
96.96
CAS Number:
[1643444-62-5]
Formula:
C20H12ClF2FeN2O2
Target:
Ferroptosis,Transferrin Receptor
Application Notes:
MCE Product type: Reference compound
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