YK-8S is a dual-targeted K-Ras (G12D/G12C) covalent inhibitor. YK-8S shows no significant binding to wild-type K-Ras and other mutants (G12R, G13D, Q61R/K). YK-8S exhibits anti-proliferative activity against H358 (G12C) and AGS (G12D) cells. YK-8S inhibits the phosphorylation of p-AKT/p-ERK in BaF3/G12D and G12C cells. YK-8S can be used for pancreatic cancer, colorectal cancer and other tumors with high incidence of G12D[1].
Molecular Weight:
628.64
Purity:
87.47
CAS Number:
[3060515-08-1]
Formula:
C34H31F3N6O3
Target:
Akt,ERK,Ras
Application Notes:
MCE Product type: Reference compound
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