CSN5-IN-1 (compound Ac-11) is an inhibitor of CSN5, with IC50 values of 12.56 µM and 19 µM as measured by FP assay and fluorescence assay, respectively. CSN5-IN-1 can also downregulate the expression of PD-L1 and upregulate the expression of NEDD8-Cul1 in cells[1].
Molecular Weight:
318.43
Formula:
C17H22N2O2S
Target:
E1/E2/E3 Enzyme,PD-1/PD-L1
Application Notes:
MCE Product type: Reference compound
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