AZD8701 (IONIS-1063734) is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs), with a human IC50 of 65.2 nM. AZD8701 binds to intronic sites of all FOXP3 pre-mRNA isoforms and mediates dose-dependent FOXP3 knockdown via free uptake. AZD8701 can be used in cancer-related research[1][2].
Molecular Weight:
5355.77
Purity:
96.61
CAS Number:
[2603457-08-3]
Target:
TGF-beta/Smad
Application Notes:
MCE Product type: Oligonucleotides
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