AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells, AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.
Molecular Weight:
410.60
Purity:
98.24
CAS Number:
[185991-24-6]
Formula:
C24H38N6
Target:
CXCR,HIV
Application Notes:
MCE Product type: Reference compound
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