BBO-10203 is a potent inhibitor of PI3Kalpha and KRASG12C, selectively and covalently binding to Cys242 in the RAS-Binding Domain of PI3Kalpha, and inhibiting both the GTP-bound and GDP-bound states of KRASG12C with an IC50 of 0.031 nM and an EC50 of 0.02 nM. BBO-10203 disrupts the interaction between RAS isoforms and PI3Kalpha, leading to the inhibition of RAS-mediated PI3Kalpha activation, and reduces pERK expression, cell growth, and induces G1 arrest and apoptosis. BBO-10203 can be used for the research of breast cancer, colorectal cancer, and non-small cell lung cancer[1][2].
Molecular Weight:
640.70
Purity:
99.12
CAS Number:
[2971769-60-3]
Formula:
C34H30F2N6O3S
Target:
Akt,PI3K,Ras
Application Notes:
MCE Product type: Reference compound
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