AChE/BChE-IN-23 (Compound 6e) is an AChE/BChE inhibitor (IC50: 0.91 µM, 1.19 µM and 1.01 µM for hAChE, eq BChE and hBChE, respectively). AChE/BChE-IN-23 has antioxidant activity and inhibits Abeta1-42 and Tau protein aggregation. AChE/BChE-IN-23 also inhibits microglial activation by reducing ROS release and mitochondrial injury. AChE/BChE-IN-23 suppresses NLRP3 inflammasome and pro-inflammatory cytokines in human microglial cells. AChE/BChE-IN-23 also reverses the Scopolamine (HY-N0296)-induced memory impairment in mice model[1].
Molecular Weight:
367.40
Formula:
C19H21N5O3
Target:
Amyloid-beta,Cholinesterase (ChE),Mitochondrial Metabolism,NOD-like Receptor (NLR),Reactive Oxygen Species (ROS),Tau Protein
Application Notes:
MCE Product type: Reference compound
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