DHFR-IN-22, CAS [[2941327-87-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-159899
Supplier Catalog Number:
HY-159899
Alternative Catalog Number:
MCE-HY-159899-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC50 of 1.1 nM and MIC of 1.5 µg/mL against M. abscessus, and an IC50 of 6.3 nM and MIC of 0.1 µg/mL against M. avium. Additionally, it demonstrates an IC50 of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections[1].
