Se2h is a cruzain inhibitor that exhibits strong activity against the intracellular amastigotes of Trypanosoma cruzi (EC50 SI > 10), with an inhibitory activity against cruzain of IC50 SI > 5.55). Compared to Benznidazole (HY-B1548) and the cruzain inhibitor K777 (HY-119293), Se2h shows superior selectivity and inhibition, while its selenazole structure reduces selenium-related toxicity. Se2h exhibits antiparasitic activity and holds promise for research in Chagas disease[1].
Molecular Weight:
359.67
Formula:
C12H13ClN4O2Se
Target:
Parasite
Application Notes:
MCE Product type: Reference compound
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