p38alpha inhibitor 6 (compound 19) is a p38alpha inhibitor with the IC50 of 0.68 µM. p38alpha inhibitor 6 induces cell apoptosis and arrests cell cycle at G0 and G2/M phase. p38alpha inhibitor 6 decreases the TNF-alpha concentration as well as increased the expression of tumor suppressor gene p53, Bax/BCL-2 ratio and caspase 3/7[1].
Molecular Weight:
499.36
Formula:
C25H19BrN6O
Target:
Apoptosis,Bcl-2 Family,Caspase,MDM-2/p53,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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