IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, with an IC50 of 5 nM for IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. IRAK1/4/pan-FLT3 Kinase-IN-1 has good pharmacokinetic properties and shows promising potential for research in acute myeloid leukemia, with a survival prolongation effect comparable to that of Gilteritinib (HY-12432)[1].
Molecular Weight:
399.46
Purity:
99.25
CAS Number:
[2760328-82-1]
Formula:
C21H26FN5O2
Target:
FLT3,IRAK
Application Notes:
MCE Product type: Reference compound
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