EOS789 is an orally active sodium-dependent phosphate transporter inhibitor, with IC50 values of 6.8, 1.5, and 1.7 µM against human NaPi-IIb, PiT-1, PiT-2, respectively, and IC50 values of 3.9, 1.9, and 1.7 µM against rat NaPi-IIb, PiT-1, PiT-2, respectively. EOS789 inhibits intestinal phosphate absorption, increases fecal phosphate excretion, reduces urinary phosphate excretion, and decreases the levels of serum phosphate, FGF23, and adult parathyroid hormone. EOS789 ameliorates ectopic thoracic aortic calcification, renal injury and hyperphosphatemia, and inhibits the expression of fibrosis markers. EOS789 can be used for the research of hyperphosphatemia and chronic kidney disease-mineral and bone disorder (CKD-MBD)[1][2].
Molecular Weight:
772.70
Purity:
99.14
CAS Number:
[1628848-73-6]
Formula:
C35H36F8N6O5
Target:
Sodium Phosphate Cotransporter
Application Notes:
MCE Product type: Reference compound
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