Ilorasertib (ABT-348) is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib also is a potent VEGF, PDGF inhibitor. Ilorasertib has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)[1][2].
Molecular Weight:
488.54
Purity:
99.86
CAS Number:
[1227939-82-3]
Formula:
C25H21FN6O2S
Target:
Aurora Kinase,PDGFR,VEGFR
Application Notes:
Reference compound
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