COX-1-IN-5 (example 13, compound PS13) is a potent and selective COX-1 inhibitor (COX-1 IC50 = 1 nM, COX-2 IC50 > 0.1 µM) exhibiting >1000-fold selectivity over COX-2. COX-1-IN-5 possesses strong anti-inflammatory, antipyretic, analgesic, antithrombotic, anti-cancer activities. COX-1-IN-5 can be used for COX-mediated diseases research, such as inflammatory conditions and pain. COX-1-IN-5 radiolabeled with 11C can be used as a selective PET tracer for whole-body imaging of COX-1 distribution and target engagement in vivo[1][2].
Molecular Weight:
379.33
CAS Number:
[524699-85-2]
Formula:
C18H16F3N3O3
Target:
COX
Application Notes:
MCE Product type: Reference compound
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