Acolbifene (EM-652) hydrochloride, an active metabolite of EM800, is an orally active, cancer-preventing selective estrogen receptor modulator (SERM). Acolbifene (EM-652) hydrochloride inhibits estradiol (E2)-induced transcriptional activity of ERalpha (IC50=2 nM) and ERbeta (IC50=0.4 nM). Acolbifene (EM-652) hydrochloride exerts a potent and pure antiestrogenic action in the mammary gland and uterus. Anticarcinogenic properties[1][2][3][4][5].
Molecular Weight:
494.02
Purity:
99.00
CAS Number:
[252555-01-4]
Formula:
C29H32ClNO4
Target:
Estrogen Receptor/ERR
Application Notes:
Reference compound
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