UGT1A1-IN-1 (Compound 2) is a non-competitive inhibitor of UGT1A1. UGT1A1-IN-1 inhibits the 1-O-glucuronidation process mediated by UGT1A1 with an IC50 and a Ki value of 1.33 and 5.02 µM. UGT1A1-IN-1 can bind on UGT1A1 at the same ligand-binding site as Bilirubin (HY-N0323). UGT1A1-IN-1 displays good reactivity in and human liver microsome (HLM). UGT1A1-IN-1 can serve as a fluorescent probe substrate for UGT1A1 or study bilirubin metabolism disorders[1].
Molecular Weight:
345.39
Purity:
99.27
CAS Number:
[2097024-37-6]
Formula:
C22H19NO3
Target:
UGT
Application Notes:
Reference compound
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