SNX281 is a systemically active non-CDN STING agonist that binds to the STING protein. SNX281 promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. SNX281 activates STING and leads to the production of type I IFNs and proinflammarory cytokines, ultimately stimulating the infilatration of immune cells into the tumor microenvironment. SNX281 enhances anti-tumor immunity, potentially overcoming resistance to checkpoint inhibitors in some cancer. SNX281 can be used in the research for anti-tumor immunity[1][2].
Molecular Weight:
389.90
Purity:
99.08
CAS Number:
[2332803-84-4]
Formula:
C20H20ClNO3S
Target:
IFNAR,STING
Application Notes:
Reference compound
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