WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 has antitumor activity[1].(Pink: UZH2 (HY-115717), Black: Linker, Blue: VHL ligand (HY-150803))
Molecular Weight:
1112.38
Purity:
98.06
Formula:
C61H75F2N11O5S
Target:
Apoptosis,METTL3,PROTACs
Application Notes:
Reference compound
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