8(9)-EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. 8(9)-EET is an effective substrate for COX-1 and COX-2. 8(9)-EET activates PPARalpha in HEK293 cells and inhibits the activity of NF-kappaB induced by IL-1beta in a PPARalpha-dependent and -independent manner. The (8S,9R)-isomer of 8(9)-EET ([(8S,9R)-EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate[1][2][3][4][5].
Molecular Weight:
320.47
CAS Number:
[82864-43-5]
Formula:
C20H32O3
Target:
COX,Drug Metabolite,NF-kappaB,PPAR
Application Notes:
MCE Product type: Reference compound
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