GW549390X is a dual inhibitor of Fluc and VEGFR2 with IC50 of 0.26 µM and 1.2 µM, respectively. GW549390X can bind to the ATP pocket of FLuc through the aniline side chain and is an ATP-competitive inhibitor of Fluc. GW549390X acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, with potential implications for Fluc reporter assays[1].
Molecular Weight:
236.27
CAS Number:
[135307-33-4]
Formula:
C15H12N2O
Target:
VEGFR
Application Notes:
MCE Product type: Reference compound
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