SGR-1505 is an oral small molecule MALT1 inhibitor with anti-proliferative and antitumor activity.SGR-1505 inhibits MALT1 enzymatic activity to modulate NF-kappaB pathway gene expression.SGR-1505 induces modulation of cell cycle, DNA damage, and apoptosis-related genes in in vivo tumor samples.SGR-1505 exerts tumorostatic and regressive activity in ABC-DLBCL xenograft models.SGR-1505 can be used for the research of activated B cell-like diffuse large B cell lymphoma, non-Hodgkin B-cell lymphomas, chronic lymphocytic leukemia, and mature B cell neoplasms[1][2][3].
Molecular Weight:
481.79
Purity:
99.89
CAS Number:
[2661481-41-8]
Formula:
C18H12ClF4N9O
Target:
Apoptosis,MALT1
Application Notes:
MCE Product type: Reference compound
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