BC-1901S is a proteasome-independent NRF2 activator and stabilizer. BC-1901S binds to DCAF1 (E3 ligase subunit) and disrupts NRF2/DCAF1 interaction, and activates NRF2 by inhibiting NRF2 ubiquitination in a KEAP1-independent manner. BC-1901S shows anti-inflammatory effect in a murine model of LPS-induced acute lung injury[1].
Molecular Weight:
424.90
Purity:
99.81
CAS Number:
[1358617-36-3]
Formula:
C23H22ClFN4O
Target:
E1/E2/E3 Enzyme,Keap1-Nrf2
Application Notes:
MCE Product type: Reference compound
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