DB07006 (compound 18) is a potent, ATP-cpmpetitive dual inhibitor of Wee1 (IC50 = 0.030 µM) and Chk1 checkpoint kinases (IC50 = 0.018 µM). DB07006 demonstrates effective abrogation of the G2/M checkpoint in combination with DNA-damaging agents in cellular models. DB07006 can be used for cancer research[1].
Molecular Weight:
416.43
CAS Number:
[622855-60-1]
Formula:
C24H20N2O5
Target:
Checkpoint Kinase (Chk),Wee1
Application Notes:
MCE Product type: Reference compound
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