CSC-6 is a NLRP3 inhibitor. CSC-6 can significantly inhibit IL-1beta secreted by PMATHP-1 cells with an IC50 value of 2.3 µM. CSC-6 specifically binds NLRP3 and inhibits NLRP3 activation by blocking ASC oligomerization during NLRP3 assembly. CSC-6 effectively reduces the symptoms of NLRP3 overactivation-mediated sepsis and gout in mouse models[1].
Molecular Weight:
395.42
Formula:
C18H12F3NO2S2
Target:
NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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