KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases[1].
Molecular Weight:
579.07
Purity:
99.14
CAS Number:
[3056394-59-0]
Formula:
C27H27ClN8O3S
Target:
Ser/Thr Kinase
Application Notes:
MCE Product type: Reference compound1
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