CBI1 formic is a covalent BAX inhibitor. CBI1 formic selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 formic blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex[1].
Molecular Weight:
461.40
Purity:
99.54
Formula:
C16H21BrN4O3S2
Target:
Bcl-2 Family
Application Notes:
Reference compound
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