Ivaltinostat (CG-200745) formic is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat formic enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU, HY-90006). Ivaltinostat formic induces apoptosis and has anti-tumour effects[1][2][3].
Molecular Weight:
473.56
Purity:
98.26
Formula:
C25H35N3O6
Target:
Apoptosis,HDAC,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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