RTx-161 is an allosteric Poltheta polymerase inhibitor with an IC50 value of 4.1 nM. RTx-161 selectively kills HR-deficient cancer cells and suppresses PARP inhibitor (PARPi) resistance in multiple genetic backgrounds, including HR-proficient cells. Additionally, RTx-161 can induce apoptosis[1].
Molecular Weight:
509.37
Purity:
98
Formula:
C21H18F7N3O4
Target:
Apoptosis,DNA/RNA Synthesis
Application Notes:
Reference compound
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