RTx-152 traps Poltheta on DNA and is an allosteric Poltheta-pol inhibitor (IC50: 6.2 nM). RTx-152 selectively kills HR-deficient cancer cells, and suppresses PARP inhibitor resistance in multiple genetic backgrounds, including homologous recombination (HR)-proficient cells. RTx-152 selectively kills BRCA2-null cells[1].
Molecular Weight:
479.35
Purity:
99.71
CAS Number:
[3035072-48-8]
Formula:
C20H16F7N3O3
Target:
DNA/RNA Synthesis
Application Notes:
Reference compound
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