SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 2 nM in human macrophages[1].
Molecular Weight:
418.51
CAS Number:
[3033846-20-4]
Formula:
C22H22N6OS
Target:
AMPK
Application Notes:
Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
