LHF418 is an effective SOS1 PROTAC degrader with a DC50 value of 209.4 nM in A549 cells. LHF418 can effectively inhibit RAS signaling and colony formation in KRAS-driven cancer cells. (Structural note: (Blue: Cereblon ligand (HY-A0003), Black: linker, Pink: SOS1 binder SOS1 Ligand intermediate-3 (HY-161452))[1].
Molecular Weight:
871.94
Formula:
C46H52F3N7O7
Target:
PROTACs,Ras
Application Notes:
MCE Product type: Reference compound1
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