BRD4/NAMPT-IN-1 (Compound A2) shows strong inhibitory effects on NAMPT and BRD4 (IC50=35 nM (NAMPT) and 58 nM (BRD4)). BRD4/NAMPT-IN-1 inhibits the growth and migration of hepatocellular carcinoma cells and promotes apoptosis. BRD4/NAMPT-IN-1 also shows potent anticancer effects in HCCLM3 xenograft mouse model, with no obvious toxic effects[1].
Molecular Weight:
588.12
Purity:
99.45
CAS Number:
[3049218-28-9]
Formula:
C30H30ClN7O2S
Target:
Epigenetic Reader Domain,NAMPT
Application Notes:
MCE Product type: Reference compound
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