LLC0424 is a potent and selective cereblon-based PROTAC nuclear receptor-binding SET domain-containing 2 (NSD2) degrader. LLC0424 effectively degraded NSD2 with a DC50 of 20 nM in RPMI-8402 cells. LLC0424 selectively induces NSD2 degradation in a cereblon- and proteasome-dependent fashion. (Blue: CRBN ligand (HY-14658), Black: linker (HY-40002), Pink: NSD2 inhibitor (HY-161575))[1].
Molecular Weight:
823.85
Purity:
98.42
Formula:
C45H41N7O9
Target:
Histone Methyltransferase,PROTACs
Application Notes:
MCE Product type: Reference compound
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