MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)-induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg)[1].
Molecular Weight:
345.37
Purity:
98.08
CAS Number:
[2099014-23-8]
Formula:
C20H16FN5
Target:
EGFR,GSK-3,IGF-1R,JAK,PI3K
Application Notes:
MCE Product type: Reference compound
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