Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 µM and 0.37 µM in dark and upon irradiation, respectively[1].
Molecular Weight:
1664.61
Formula:
C89H75Cl2N11O11Ru.7H2O
Target:
Ferroptosis,Ligands for E3 Ligase
Application Notes:
MCE Product type: Reference compound1
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