GAT2711 is a full agonist of alpha9 nAChR with an EC50 of 230 nM. GAT2711 shows 340-fold selective for alpha9 over alpha7 nAChRs. GAT2711 inhibits ATP-induced IL-1beta release in THP-1 cells. GAT2711 retains full analgesic activity in alpha7 nAChR knockout mice[1].
Molecular Weight:
466.36
Purity:
98.00
Formula:
C20H27IN4O
Target:
nAChR
Application Notes:
MCE Product type: Reference compound1
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