PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709), Black: linker (HY-W012935), Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))[1]
Molecular Weight:
770.84
Formula:
C40H42N12O5
Target:
CDK,FLT3,PROTACs
Application Notes:
MCE Product type: Reference compound1
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