LH2-051, a lysosome-enhancing compound (LYEC), is a brain-penetrant dopamine transporter (DAT) inhibitor (Ki: 0.95 µM). LH2-051 inhibits DAT-mediated dopamine uptake with an IC50 of 3.0 µM. LH2-051 promotes nuclear translocation of TFEB and lysosome biogenesis. LH2-051 improves the memory of amyloid precursor protein (APP)/Presenilin 1 (PS1) mice. LH2-051 can be used for the study of Alzheimers disease[1].
Molecular Weight:
434.57
Purity:
99.85
CAS Number:
[2358754-22-8]
Formula:
C27H34N2O3
Target:
CDK,Dopamine Transporter
Application Notes:
MCE Product type: Reference compound1
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