P2Y14R antagonist 1 (compound I-17) is a selective P2Y14R antagonist with an IC50 of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis[1].
Molecular Weight:
346.18
Purity:
98.76
CAS Number:
[2728291-29-8]
Formula:
C15H12BrN3O2
Target:
NOD-like Receptor (NLR),P2Y Receptor
Application Notes:
MCE Product type: Reference compound
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