Fumagilin-105 is an autophagy-targeting chimera (AUTOTAC) that degrades MetAP2 via p62-mediated macroautophagy in a ubiquitination-independent manner. Fumagilin-105 can inhibit the migration of tumor cells and induce programmed cell death. Fumagilin-105 has anti-tumor activity. (p62-ZZ ligand (HY-W489121), target-binding ligand (HY-B0751), linker (HY-W245803))[1].
Molecular Weight:
784.98
Purity:
97.34
CAS Number:
[2410081-58-0]
Formula:
C46H60N2O9
Target:
Autophagy,AUTOTACs,MetAP,p62
Application Notes:
MCE Product type: Reference compound
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