PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 TFA selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 TFA increases the autophagic flux of Ub-conjugated aggregates[1].
Molecular Weight:
754.83
Purity:
99.58
Formula:
C41H49F3N2O8
Target:
Autophagy,AUTOTACs
Application Notes:
MCE Product type: Reference compound
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