Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) that targets p62/Sequestosome-1/SQSTM1. Anle138b-F105 binds to the ZZ domain of p62, induces conformational activation, self-oligomerization, interaction with LC3, and formation of autophagosomes. Anle138b-F105 induces autophagic flux of ubiquitin-conjugated aggregated proteins, leading to their lysosomal degradation. Anle138b-F105 is applicable for the research of neurodegenerative proteinopathies[1].
Molecular Weight:
624.70
Purity:
98.59
CAS Number:
[2941386-44-1]
Formula:
C36H37FN4O5
Target:
Autophagy,AUTOTACs
Application Notes:
MCE Product type: Reference compound1
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